Article
Visualised genotyping assay with oral swabs in a closed tube by nested invasive reaction assisted with gold nanoparticle probes.
IET nanobiotechnology - 1 May 2023
Li Yijun, Wei Wei, Ma Yi, Shan Jingwen, Chu Yanan, Zhang LiKun, Liu Danni, Ma Xueping, Zhou Guohua, Wu Haiping
Abstract excerpt
Single nucleotide polymorphism (SNP) typing is crucial for drug dosage and disease progression. Therefore, a simple and convenient genotyping assay is essential for personalised medicine. Herein, we developed a non-invasive, closed-tube, and visualised method for genotyping. In this method, oral swabs were lysed to directly perform PCR coupled with nested invasive reaction and visualisation based on gold...
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