Article
Subnuclear localisation is associated with gene expression more than parental origin at the imprinted Dlk1-Dio3 locus.
PLoS genetics - 1 Apr 2022
Mashoodh Rahia, Hülsmann Lisa C, Dearden Frances L, Takahashi Nozomi, Edwards Carol, Ferguson-Smith Anne C
Abstract excerpt
At interphase, de-condensed chromosomes have a non-random three-dimensional architecture within the nucleus, however, little is known about the extent to which nuclear organisation might influence expression or vice versa. Here, using imprinting as a model, we use 3D RNA- and DNA-fluorescence-in-situ-hybridisation in normal and mutant mouse embryonic stem cell lines to assess the relationship between imprinting...
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