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Article

Germline mutations in penetrant cancer predisposition genes are rare in men with prostate cancer selecting active surveillance.

Cancer medicine - 1 Nov 2022

Brady Lauren, Newcomb Lisa F, Zhu Kehao, Zheng Yingye, Boyer Hilary, Sarkar Navonil De, McKenney Jesse K, Brooks James D, Carroll Peter R, Dash Atreya, Ellis William J, Filson Christopher P, Gleave Martin E, Liss Michael A, Martin Frances, Morgan Todd M, Thompson Ian M, Wagner Andrew A, Pritchard Colin C, Lin Daniel W, Nelson Peter S

Abstract excerpt

BACKGROUND: Pathogenic germline mutations in several rare penetrant cancer predisposition genes are associated with an increased risk of aggressive prostate cancer (PC). Our objectives were to determine the prevalence of pathogenic germline mutations in men with low-risk PC on active surveillance, and assess whether pathogenic germline mutations associate with grade reclassification or adverse pathology,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35467778
DOI: 10.1002/cam4.4778
PMCID: PMC9678104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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