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Article

The 'Prostate Cancer Screening for People at Genetic Risk of Aggressive Disease' (PATROL) study.

BJU international - 1 Oct 2026

Cheng Heather H, Maxwell Kara N, Salari Keyan, Cooperberg Matthew R, Follmer Kristin, Jeter Joanne M, Jun Grace, Lee Daniel J, Patel Hiten D, Schaeffer Edward M, Sokolova Alexandra O, Wolff Erika M, Lin Daniel W

Abstract excerpt

BACKGROUND: Inherited (germline) pathogenic and likely pathogenic variants (gPVs) in key genes associated with increased risk of prostate cancer (PCa) now warrant more attentive PCa screening per National Comprehensive Cancer Network (NCCN) guidelines-e.g., BRCA2, HOXB13, ATM, BRCA1, MSH2, MSH6, CHEK2 and TP53. However, the optimal early detection strategy for gPV carriers, including use of age-adjusted PSA...

Read the complete abstract on PubMed

Topics

Humans
Male
Middle Aged
Early Detection of Cancer
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Testing

Magnetic Resonance Imaging

Prospective Studies

Prostate-Specific Antigen

Prostatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 42265755
DOI: 10.1111/bju.70334
PMCID: PMC13550811

Genes

ATM
BRCA1
BRCA2
CHEK2
HOXB13
MSH2
MSH6
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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