Article
A stop-gain mutation in GXYLT1 promotes metastasis of colorectal cancer via the MAPK pathway.
Cell death & disease - 22 Apr 2022
Peng Lin, Zhao Min, Liu Tianqi, Chen Jiangbo, Gao Pin, Chen Lei, Xing Pu, Wang Zaozao, Di Jiabo, Xu Qiang, Qu Hong, Jiang Beihai, Su Xiangqian
Abstract excerpt
Genomic instability plays a key role in the initiation and progression of colorectal cancer (CRC). Although cancer driver genes in CRC have been well characterized, identifying novel genes associated with carcinogenesis and treatment remains challenging because of tumor heterogeneity. Here, we analyzed the genomic alterations of 45 samples from CRC patients in northern China by whole-exome sequencing. In addition...
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