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Article

Genome-wide mutation profiles of colorectal tumors and associated liver metastases at the exome and transcriptome levels.

Oncotarget - 8 Sept 2015

Lim Byungho, Mun Jihyeob, Kim Jeong-Hwan, Kim Chan Wook, Roh Seon Ae, Cho Dong-Hyung, Kim Yong Sung, Kim Seon-Young, Kim Jin Cheon

Abstract excerpt

To characterize the mutation profiles of colorectal cancer (CRC) primary tumors (PTs) and liver metastases (CLMs), we performed both whole-exome and RNA sequencing. Ten significantly mutated genes, including BMI1, CARD11, and NRG1, were found in 34 CRCs with CLMs. We defined three mutation classes (Class 1 to 3) based on the absence or presence of mutations during liver metastasis. Most mutations were classified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26109429
DOI: 10.18632/oncotarget.4246
PMCID: PMC4673155

Genes

APC
BMI1
CARD11
NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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