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Article

A somatic mutation in moesin drives progression into acute myeloid leukemia.

Science advances - 22 Apr 2022

Yuan Ouyang, Ugale Amol, de Marchi Tommaso, Anthonydhason Vimala, Konturek-Ciesla Anna, Wan Haixia, Eldeeb Mohamed, Drabe Caroline, Jassinskaja Maria, Hansson Jenny, Hidalgo Isabel, Velasco-Hernandez Talia, Cammenga Jörg, Magee Jeffrey A, Niméus Emma, Bryder David

Abstract excerpt

Acute myeloid leukemia (AML) arises when leukemia-initiating cells, defined by a primary genetic lesion, acquire subsequent molecular changes whose cumulative effects bypass tumor suppression. The changes that underlie AML pathogenesis not only provide insights into the biology of transformation but also reveal novel therapeutic opportunities. However, backtracking these events in transformed human AML samples is...

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Identifiers

PMID: 35442741
DOI: 10.1126/sciadv.abm9987
PMCID: PMC9020775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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