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Article

Rational redesign of neutral endopeptidase binding to merlin and moesin proteins.

Protein science : a publication of the Protein Society - 1 May 2009

Niv Masha Y, Iida Katsuyuki, Zheng Rong, Horiguchi Akio, Shen Ruoqian, Nanus David M

Abstract excerpt

Neutral endopeptidase (NEP) is a 90- to 110-kDa cell-surface peptidase that is normally expressed by numerous tissues but whose expression is lost or reduced in a variety of malignancies. The anti-tumorigenic function of NEP is mediated not only by its catalytic activity but also through direct protein-protein interactions of its cytosolic region with several binding partners, including Lyn kinase, PTEN, and...

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Source

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Identifiers

PMID: 19388049
DOI: 10.1002/pro.114
PMCID: PMC2771306

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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