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GATA3 and MDM2 are synthetic lethal in estrogen receptor-positive breast cancers

19 Apr 2022

Abstract excerpt

Synthetic lethal interactions, where the simultaneous but not individual inactivation of two genes is lethal to the cell, have been successfully exploited to treat cancer. GATA3 is frequently mutated in estrogen receptor (ER)-positive breast cancers and its deficiency defines a subset of patients with poor response to hormonal therapy and poor prognosis. However, GATA3 is not yet targetable. Here we show that...

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PMID: 35440675
DOI: 10.1038/s42003-022-03296-x

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