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Article

Targeting X-linked inhibitor of apoptosis protein to increase the efficacy of endoplasmic reticulum stress-induced apoptosis for melanoma therapy.

The Journal of investigative dermatology - 1 Sept 2010

Hiscutt Emma L, Hill David S, Martin Shaun, Kerr Ryan, Harbottle Andrew, Birch-Machin Mark, Redfern Christopher P F, Fulda Simone, Armstrong Jane L, Lovat Penny E

Abstract excerpt

Melanoma remains notoriously resistant to current chemotherapeutics, leaving an acute need for novel therapeutic approaches. The aim of this study was to determine the prognostic and therapeutic significance of X-linked inhibitor of apoptosis protein (XIAP) in melanoma through correlation of XIAP expression with disease stage, RAS/RAF mutational status, clinical outcome, and susceptibility to endoplasmic...

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Identifiers

PMID: 20520630
DOI: 10.1038/jid.2010.146

Genes

XIAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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