Article

NLRP1 Shapes Immune and Inflammatory Signatures in Human Melanoma but Not in Mouse Models

2025-11-26

Abstract excerpt

Inflammasomes are multiprotein complexes that activate pro-caspase-1, leading to the maturation of the pro-inflammatory cytokines IL-1β and IL-18. Nlrp1 , the first receptor identified with inflammasome-forming capacity, is highly expressed in both the skin and immune cells. Despite its prominent role in these tissues, the function of Nlrp1 in melanoma remains poorly characterized. In this study, we investigated...

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Literature Corpus work: d94f9a0c-eb54-585d-a4a6-c7b2e3821988
DOI: 10.1101/2025.11.24.690170

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