Article
Mechanistic Translation of Melanoma Genetic Landscape in Enriched Pathways and Oncogenic Protein-Protein Interactions.
Cancer genomics & proteomics - 1 Jan 2000
Massimino Michele, Stella Stefania, Micale Giovanni, Motta Lucia, Pavone Giuliana, Broggi Giuseppe, Piombino Eliana, Magro Gaetano, Soto Parra Hector Jose, Manzella Livia, Vigneri Paolo
Abstract excerpt
BACKGROUND/AIM: Malignant melanoma is a skin cancer originating from the oncogenic transformation of melanocytes located in the epidermal layers. Usually, the patient's prognosis depends on timing of disease detection and molecular and genetic profiling, which may all significantly influence mortality rates. Genetic analyses often detect somatic BRAF, NRAS and cKIT mutations, germline substitutions in CDKN2A, and...
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