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Melanoma genomics - will we go beyond BRAF in clinics?

Journal of cancer research and clinical oncology - 28 Sept 2024

Mirek Justyna, Bal Wiesław, Olbryt Magdalena

Abstract excerpt

In the era of next-generation sequencing, the genetic background of cancer, including melanoma, appears to be thoroughly established. However, evaluating the oncogene BRAF mutation in codon V600 is still the only companion diagnostic genomic test commonly implemented in clinics for molecularly targeted treatment of advanced melanoma. Are we wasting the collected genomic data? Will we implement our current genomic...

Topics

Humans
Melanoma
Proto-Oncogene Proteins B-raf
Genomics
Mutation
High-Throughput Nucleotide Sequencing
Biomarkers, Tumor
Skin Neoplasms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39340537
DOI: 10.1007/s00432-024-05957-2
PMCID: PMC11438618

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