Article
Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.
Scientific reports - 24 Nov 2016
Lasica Anna M, Goulas Theodoros, Mizgalska Danuta, Zhou Xiaoyan, de Diego Iñaki, Ksiazek Mirosław, Madej Mariusz, Guo Yonghua, Guevara Tibisay, Nowak Magdalena, Potempa Barbara, Goel Apoorv, Sztukowska Maryta, Prabhakar Apurva T, Bzowska Monika, Widziolek Magdalena, Thøgersen Ida B, Enghild Jan J, Simonian Mary, Kulczyk Arkadiusz W, Nguyen Ky-Anh, Potempa Jan, Gomis-Rüth F Xavier
Abstract excerpt
Porphyromonas gingivalis is a member of the human oral microbiome abundant in dysbiosis and implicated in the pathogenesis of periodontal (gum) disease. It employs a newly described type-IX secretion system (T9SS) for secretion of virulence factors. Cargo proteins destined for secretion through T9SS carry a recognition signal in the conserved C-terminal domain (CTD), which is removed by sortase PorU during...
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