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Article

Structural analysis of a specialized type III secretion system peptidoglycan-cleaving enzyme.

The Journal of biological chemistry - 17 Apr 2015

Burkinshaw Brianne J, Deng Wanyin, Lameignère Emilie, Wasney Gregory A, Zhu Haizhong, Worrall Liam J, Finlay B Brett, Strynadka Natalie C J

Abstract excerpt

The Gram-negative bacterium enteropathogenic Escherichia coli uses a syringe-like type III secretion system (T3SS) to inject virulence or "effector" proteins into the cytoplasm of host intestinal epithelial cells. To assemble, the T3SS must traverse both bacterial membranes, as well as the peptidoglycan layer. Peptidoglycan is made of repeating N-acetylmuramic acid and N-acetylglucosamine disaccharides...

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Identifiers

PMID: 25678709
DOI: 10.1074/jbc.M115.639013
PMCID: PMC4400350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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