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Article

SNP rs322931 (C>T) in miR-181b and rs7158663 (G>A) in MEG3 aggravate the inflammatory response of anal abscess in patients with Crohn's disease.

Aging - 14 Apr 2022

Zhong Chaoxiang, Yao Qiuju, Han Jing, Yang Jie, Jiang Fei, Zhang Qiong, Zhou Haiyi, Hu Yuchao, Wang Wei, Zhang Yan, Sun Ye

Abstract excerpt

BACKGROUND: The MEG3/miR-181b signaling has been implicated in the pathogenesis of several diseases including Crohn's disease. This work aimed to study the correlation between SNPs in MEG3/miR-181b and the severity of anal abscess in patients with Crohn's disease. METHODS: Quantitative real-time PCR was performed to analyze the expression of MEG3 and miR-181b. ELISA was carried out to examine the expression of...

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PMID: 35422450
DOI: 10.18632/aging.204014
PMCID: PMC9037263

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