Article
Increased expression of IL12B mRNA transcribed from the risk haplotype for Crohn's disease is a risk factor for disease relapse in Japanese patients.
Journal of gastroenterology - 1 Dec 2017
Kakuta Yoichi, Kimura Tomoya, Negoro Kenichi, Kuroha Masatake, Shiga Hisashi, Endo Katsuya, Kinouchi Yoshitaka, Shimosegawa Tooru
Abstract excerpt
BACKGROUND: IL12B is a promising candidate for a susceptibility gene in Crohn's disease (CD). The aim of this study was to perform a candidate gene analysis of IL12B in Japanese CD patients, investigate whether the genotype is associated with disease phenotypes, and determine how the risk allele affects susceptibility to CD. METHODS: Three hundred seventy-five patients with CD, 265 patients with ulcerative...
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