Article
T-cell activation Rho GTPase-activating protein expression varies with inflammation location and severity in Crohn's disease.
The Journal of surgical research - 1 Aug 2014
Connelly Tara M, Berg Arthur S, Harris Leonard R, Hegarty John P, Ruggiero Francesca M, Deiling Susan M, Brinton David L, Koltun Walter A
Abstract excerpt
BACKGROUND: The T-cell activation Rho GTPase-activating protein (TAGAP) gene has a regulatory role in T cell activation. We have previously suggested a correlation between the TAGAP-associated single nucleotide polymorphism rs212388 and protection from anal sepsis in Crohn's disease (CD) patients. The present study sought to evaluate TAGAP's expression in colonic tissue of CD patients with varying disease...
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