Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition.

Leukemia - 1 Sept 2024

Chaudhry Sana, Beckedorff Felipe, Jasdanwala Shaista Shabbir, Totiger Tulasigeri M, Affer Maurizio, Lawal Abimbola Eunice, Montoya Skye, Tamiro Francesco, Tonini Olivia, Chirino Alexandra, Adams Andrew, Sondhi Anya K, Noudali Stephen, Cornista Alyssa Mauri, Nicholls Miah, Afaghani Jumana, Robayo Paola, Bilbao Daniel, Nimer Stephen D, Rodríguez Jose Antonio, Bhatt Shruti, Wang Eric, Taylor Justin

Abstract excerpt

SF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of XPO1 inhibitors, selinexor and eltanexor, in high-risk myelodysplastic neoplasms (MDS) revealed responders were enriched with SF3B1 mutations. Given that XPO1 (Exportin-1) is a nuclear exporter responsible for the export of proteins and multiple RNA species, this led to the hypothesis that SF3B1-mutant cells are sensitive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-X Protein
Share to Bridged Bicyclo Compounds, Heterocyclic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exportin 1 Protein

Share to Hydrazines

Share to Karyopherins

Share to RNA Splicing Factors

Share to RNA Transport

Share to Triazoles

Source

Open in PubMed Open full text

Identifiers

PMID: 38997434
DOI: 10.1038/s41375-024-02328-1
PMCID: PMC11347370

Genes

SF3B1
XPO1
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition.PMID 38997434Read ↗

Protein biomarkers for response to XPO1 inhibition in haematologic malignanciesSemantic proximity Read ↗

XPO1 in B cell hematological malignancies: from recurrent somatic mutations to targeted therapy.Semantic proximity Read ↗

Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemiaSemantic proximity Read ↗

Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B-cell lymphoma.Semantic proximity Read ↗

Impact of Pan-Cancer Analysis of The Exportins Family on Prognosis, The Tumour Microenvironment and Its Potential Therapeutic EfficacySemantic proximity Read ↗

E3 ubiquitin ligase ASB8 promotes selinexor-induced proteasomal degradation of XPO1Semantic proximity Read ↗

SF3B1 mutation-mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia.Semantic proximity Read ↗

Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.Semantic proximity Read ↗

Targeting nuclear import and export in hematological malignanciesSemantic proximity Read ↗

The past, present, and future of CRM1/XPO1 inhibitorsSemantic proximity Read ↗

Multi-level systems analysis identifies XPO1 as a druggable target linked to NFκB activation, proliferation, tumor clonality and long-term survival in Adult T-cell LeukemiaSemantic proximity Read ↗

The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.