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Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer

14 Apr 2022

Abstract excerpt

Sex bias exists in the development and progression of nonreproductive organ cancers, but the underlying mechanisms are enigmatic. Studies so far have focused largely on sexual dimorphisms in cancer biology and socioeconomic factors. Here, we establish a role for CD8 + T cell–dependent antitumor immunity in mediating sex differences in tumor aggressiveness, which is driven by the gonadal androgen but not sex...

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PMID: 35420889
DOI: 10.1126/sciimmunol.abq2630

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