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Article

B7-H1–Dependent Sex-Related Differences in Tumor Immunity and Immunotherapy Responses

5 Aug 2010

Abstract excerpt

CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) are immunopathogenic in cancers by impeding tumor-specific immunity. B7-homologue 1 (B7-H1) (CD274) is a cosignaling molecule with pleiotropic effects, including hindering antitumor immunity. In this study, we demonstrate sex-dependent, B7-H1-dependent differences in tumor immunity and response to immunotherapy in a hormone-independent cancer, murine B16 melanoma....

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Identifiers

PMID: 20686128
DOI: 10.4049/jimmunol.1000496

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