Article
Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα.
Nature communications - 13 Apr 2022
Nam Hyeri, Lee Younghwan, Kim Boil, Lee Ji-Won, Hwang Seohyeon, An Hyun-Kyu, Chung Kyung Min, Park Youngjin, Hong Jihyun, Kim Kyungjin, Kim Eun-Kyoung, Choe Han Kyoung, Yu Seong-Woon
Abstract excerpt
Hyperimmunity drives the development of Alzheimer disease (AD). The immune system is under the circadian control, and circadian abnormalities aggravate AD progress. Here, we investigate how an AD-linked mutation deregulates expression of circadian genes and induces cognitive decline using the knock-in (KI) mice heterozygous for presenilin 2 N141I mutation. This mutation causes selective overproduction of clock...
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