Article

Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα

2020-11-18

Abstract excerpt

Hyperimmunity drives the development of Alzheimer disease (AD). The immune system is under the circadian control, and circadian abnormalities aggravate AD progress. Here, we investigated how an AD-linked mutation deregulates expression of circadian genes and induces cognitive decline using the knock-in (KI) mice heterozygous for presenilin 2 (Psen2) N141I mutation. This mutation causes overproduction of clock-cont...

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Literature Corpus work: ea9bfc89-894a-53b1-ab67-82f011426927
DOI: 10.21203/rs.3.rs-102825/v1

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