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Article

Cell-Type Transcriptome Atlas of Human Aortic Valves Reveal Cell Heterogeneity and Endothelial to Mesenchymal Transition Involved in Calcific Aortic Valve Disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2020

Xu Kang, Xie Shangbo, Huang Yuming, Zhou Tingwen, Liu Ming, Zhu Peng, Wang Chunli, Shi Jiawei, Li Fei, Sellke Frank W, Dong Nianguo

Abstract excerpt

OBJECTIVE: Leaflet thickening, fibrosis, and hardening are early pathological features of calcific aortic valve disease (CAVD). An inadequate understanding of the resident aortic valve cells involved in the pathological process may compromise the development of therapeutic strategies. We aim to construct a pattern of the human aortic valve cell atlas in healthy and CAVD clinical specimens, providing insight into...

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PMID: 33086873
DOI: 10.1161/ATVBAHA.120.314789

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