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Article

Kinetics and determinants of ESR1 mutation detection in metastatic breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Mar 2026

Cabel L, Berger F, Bachelot T, Pistilli B, Dalenc F, de la Motte Rouge T, Sabatier R, Lortholary A, Marques S, Vibert J, Renault S, Hardy-Bessard A C, Delaloge S, Pradines A, Callens C, Bidard F C

Abstract excerpt

BACKGROUND: PADA-1 was the first prospective randomized trial to show that early therapeutic targeting of blood ESR1 mutations (bESR1-mut) with fulvestrant provides significant clinical benefit in patients with estrogen receptor α-positive/human epidermal growth factor receptor 2-negative advanced breast cancer treated with an aromatase inhibitor and palbociclib. Here, we describe the kinetics and determinants of...

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Acrylamides
Antineoplastic Combined Chemotherapy Protocols
Aromatase Inhibitors
Circulating Tumor DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Estrogen Receptor alpha

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Identifiers

PMID: 41260263
DOI: 10.1016/j.annonc.2025.11.002

Genes

ESR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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