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Article

OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer

12 Apr 2022

Abstract excerpt

Androgen and androgen receptor (AR) targeted therapies are the main treatment for most prostate cancer (PC) patients. Although AR signaling inhibitors are effective, tumors can evade this treatment by transforming to an AR-negative PC via lineage plasticity. OCT1 is a transcription factor interacting with the AR to enhance signaling pathways involved in PC progression, but its role in the emergence of the...

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PMID: 35413990
DOI: 10.1038/s41598-022-10099-x

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