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Article

De novo mutations in children born after medical assisted reproduction.

Human reproduction (Oxford, England) - 30 May 2022

Smits R M, Xavier M J, Oud M S, Astuti G D N, Meijerink A M, de Vries P F, Holt G S, Alobaidi B K S, Batty L E, Khazeeva G, Sablauskas K, Vissers L E L M, Gilissen C, Fleischer K, Braat D D M, Ramos L, Veltman J A

Abstract excerpt

STUDY QUESTION: Are there more de novo mutations (DNMs) present in the genomes of children born through medical assisted reproduction (MAR) compared to spontaneously conceived children? SUMMARY ANSWER: In this pilot study, no statistically significant difference was observed in the number of DNMs observed in the genomes of MAR children versus spontaneously conceived children. WHAT IS KNOWN ALREADY: DNMs are known...

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Identifiers

PMID: 35413117
DOI: 10.1093/humrep/deac068
PMCID: PMC9156847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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