Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study.

doi:10.1038/s41422-021-00521-w

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Article

Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study.

Cell research - 1 Aug 2021

Wang Cheng, Lv Hong, Ling Xiufeng, Li Hong, Diao Feiyang, Dai Juncheng, Du Jiangbo, Chen Ting, Xi Qi, Zhao Yang, Zhou Kun, Xu Bo, Han Xiumei, Liu Xiaoyu, Peng Meijuan, Chen Congcong, Tao Shiyao, Huang Lei, Liu Cong, Wen Mingyang, Jiang Yangqian, Jiang Tao, Lu Chuncheng, Wu Wei, Wu Di, Chen Minjian, Lin Yuan, Guo Xuejiang, Huo Ran, Liu Jiayin, Ma Hongxia, Jin Guangfu, Xia Yankai, Sha Jiahao, Shen Hongbing, Hu Zhibin

Abstract excerpt

Emerging evidence suggests that children conceived through assisted reproductive technology (ART) have a higher risk of congenital heart defects (CHDs) even when there is no family history. De novo mutation (DNM) is a well-known cause of sporadic congenital diseases; however, whether ART procedures increase the number of germline DNM (gDNM) has not yet been well studied. Here, we performed whole-genome sequencing...

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Identifiers

PMID: 34108666
DOI: 10.1038/s41422-021-00521-w
PMCID: PMC8324888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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