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Article

Spacer Domain in Hepatitis B Virus Polymerase: Plugging a Hole or Performing a Role?

Journal of virology - 11 May 2022

Pley Caitlin, Lourenço José, McNaughton Anna L, Matthews Philippa C

Abstract excerpt

Hepatitis B virus (HBV) polymerase is divided into terminal protein, spacer, reverse transcriptase, and RNase domains. Spacer has previously been considered dispensable, merely acting as a tether between other domains or providing plasticity to accommodate deletions and mutations. We explore evidence for the role of spacer sequence, structure, and function in HBV evolution and lineage, consider its associations...

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Identifiers

PMID: 35412348
DOI: 10.1128/jvi.00051-22
PMCID: PMC9093120

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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