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Article

Multiple roles of core protein linker in hepatitis B virus replication

21 May 2018

Abstract excerpt

Hepatitis B virus (HBV) core protein (HBc) contains an N-terminal domain (NTD, assembly domain) and a C-terminal domain (CTD), which are linked by a flexible linker region. HBc plays multiple essential roles in viral replication, including capsid assembly, packaging of the viral pregenomic RNA (pgRNA) into nucleocapsids, viral reverse transcription that converts pgRNA to the genomic DNA, and secretion of...

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PMID: 29782550
DOI: 10.1371/journal.ppat.1007085

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