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Article

Molecular, Evolutionary, and Structural Analysis of the Terminal Protein Domain of Hepatitis B Virus Polymerase, a Potential Drug Target.

Viruses - 22 May 2020

Buhlig Timothy S, Bowersox Anastasia F, Braun Daniel L, Owsley Desiree N, James Kortney D, Aranda Alfredo J, Kendrick Connor D, Skalka Nicole A, Clark Daniel N

Abstract excerpt

Approximately 250 million people are living with chronic hepatitis B virus (HBV) infections, which claim nearly a million lives annually. The target of all current HBV drug therapies (except interferon) is the viral polymerase; specifically, the reverse transcriptase domain. Although no high-resolution structure exists for the HBV polymerase, several recent advances have helped to map its functions to specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32455999
DOI: 10.3390/v12050570
PMCID: PMC7291194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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