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Article

Probing Photoreceptor Outer Segment Phagocytosis by the RPE In Vivo: Models and Methodologies

27 Mar 2022

Abstract excerpt

In the vertebrate retina, the light-sensitive photoreceptor rods and cones constantly undergo renewal by generating new portions of the outer segment and shedding their distal, spent tips. The neighboring RPE provides the critical function of engulfing the spent material by phagocytosis. RPE phagocytosis of shed rod outer segment fragments is a circadian process that occurs in a burst of activity shortly after...

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PMID: 35409021
DOI: 10.3390/ijms23073661

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