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Article

Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium

29 May 2018

Abstract excerpt

The retinal pigment epithelium (RPE) transports nutrients and metabolites between the microvascular bed that maintains the outer retina and photoreceptor neurons. The RPE removes photoreceptor outer segments (POS) by receptor-mediated phagocytosis, a process that peaks in the morning. Uptake and degradation of POS initiates signaling cascades in the RPE. Upstream stimuli from various metabolic activities converge...

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PMID: 29844054
DOI: 10.1126/scisignal.aag3315

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