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Article

Phagocytosis-dependent ketogenesis in retinal pigment epithelium.

The Journal of biological chemistry - 12 May 2017

Reyes-Reveles Juan, Dhingra Anuradha, Alexander Desiree, Bragin Alvina, Philp Nancy J, Boesze-Battaglia Kathleen

Abstract excerpt

Daily, the retinal pigment epithelium (RPE) ingests a bolus of lipid and protein in the form of phagocytized photoreceptor outer segments (OS). The RPE, like the liver, expresses enzymes required for fatty acid oxidation and ketogenesis. This suggests that these pathways play a role in the disposal of lipids from ingested OS, as well as providing a mechanism for recycling metabolic intermediates back to the outer...

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Identifiers

PMID: 28302729
DOI: 10.1074/jbc.M116.770784
PMCID: PMC5427279

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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