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Article

No association between APOE genotype and lipid lowering with cognitive function in a randomized controlled trial of evolocumab.

PloS one - 1 Jan 2022

Korthauer Laura E, Giugliano Robert P, Guo Jianping, Sabatine Marc S, Sever Peter, Keech Anthony, Atar Dan, Kurtz Christopher, Ruff Christian T, Mach Francois, Ott Brian R

Abstract excerpt

APOE encodes a cholesterol transporter, and the ε4 allele is associated with higher circulating cholesterol levels, ß-amyloid burden, and risk of Alzheimer's disease. Prior studies demonstrated no significant differences in objective or subjective cognitive function for patients receiving the PCSK9 inhibitor evolocumab vs. placebo added to statin therapy. There is some evidence that cholesterol-lowering...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35404972
DOI: 10.1371/journal.pone.0266615
PMCID: PMC9000128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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