Development of Hydrocephalus in Mice Expressing the G_i-Coupled GPCR Ro1 RASSL Receptor in Astrocytes

Abstract excerpt

We developed a transgenic mouse line that expresses the G(i)-coupled RASSL (receptor activated solely by synthetic ligand) Ro1 in astrocytes to study astrocyte-neuronal communication. Surprisingly, we found that all transgenics expressing Ro1 developed hydrocephalus. We analyzed these mice in an effort to develop a new model of hydrocephalus that will further our understanding of the pathophysiology of the...

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