Article

Evaluating the causal impact of reproductive factors on breast cancer risk: a multivariable mendelian randomization approach

2024-02-03

Abstract excerpt

<h4>Background</h4> Observational evidence proposes a protective effect of having children and an early age at first birth on the development of breast cancer, however the causality of this association remains uncertain. In this study we assess whether these reproductive factors impact breast cancer risk independently of age at menarche, age at menopause, adiposity measures and other reproductive factors that have...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5fc89cb4-f608-59b9-8f3e-de2c2ed42f12
DOI: 10.1101/2024.02.02.24301815

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evaluating the causal impact of reproductive factors on breast cancer risk: a multivariable mendelian randomization approachDOI 10.1101/2024.02.02.24301815Read

Establishing the relationships between adiposity and reproductive factors: a multivariable Mendelian randomization analysisSemantic proximity Read

The relationships between women’s reproductive factors: a Mendelian randomization analysisSemantic proximity Read

Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization.Semantic proximity Read

Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk.Semantic proximity Read

Natural menopause, menarche and breast cancer risk in BRCA1 and BRCA2 pathogenic variant carriers: a Mendelian randomization analysis.Semantic proximity Read

Investigating the genetic causal relationship between breast cancer and endometrial cancer: A two-sample Mendelian randomization study.Semantic proximity Read

Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization studySemantic proximity Read

Reproductive factors and breast cancer risk among BRCA1 or BRCA2 mutation carriers: results from ten studies.Semantic proximity Read

Causal effect of breast cancer on endometrial cancer risk: A two-sample Mendelian randomization study.Semantic proximity Read

Genetic liability to age at first sex and birth in relation to cardiovascular diseases: a Mendelian randomization study.Semantic proximity Read

Dissecting Causal Pathways Using Mendelian Randomization with Summarized Genetic Data: Application to Age at Menarche and Risk of Breast Cancer.Semantic proximity Read

Reproductive windows, genetic loci, and breast cancer risk.Semantic proximity Read