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Article

PTEN inhibitor attenuates cardiac fibrosis by regulating the M2 macrophage phenotype via the PI3K/AKT/TGF-β/Smad 2/3 signaling pathway.

International journal of cardiology - 1 Jun 2022

Zhuang Chenchen, Guo Ziyi, Zhu Jumo, Wang Wenjuan, Sun Runmin, Qi Miaomiao, Wang Qiongying, Fan Xin, Ma Runxin, Yu Jing

Abstract excerpt

Cardiac fibrosis is a key feature of hypertensive cardiac remodeling. In response to microenvironmental stimuli, phenotypic and functional changes in macrophages are considered important determinants of cardiac fibrosis attenuation. VO-OHpic, a phosphatase and tension homolog of chromosome 10 (PTEN) inhibitor, has been demonstrated to be cardioprotective in cardiac remodeling. However, whether VO-OHpic can...

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Identifiers

PMID: 35395283
DOI: 10.1016/j.ijcard.2022.04.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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