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Article

Pseudolaric Acid B Attenuates High Salt Intake-Induced Hypertensive Left Ventricular Remodeling by Modulating Monocyte/Macrophage Phenotypes.

Medical science monitor : international medical journal of experimental and clinical research - 8 Sept 2021

Yu Fang-Fang, Yang Guo-Hong, Chen Shao-Bo, Niu Xiu-Long, Cai Wei, Tao Yan-Yan, Wang Xiu-Juan, Li Ming, Li Yu-Ming, Zhao Ji-Hong

Abstract excerpt

BACKGROUND Studies in ApoE knockout mice have shown that pseudolaric acid B (PB) can act as an immunomodulatory drug and attenuate atherosclerosis progression by modulating monocyte/macrophage phenotypes. Our previous study demonstrated that high salt intake could shift the phenotype of monocytes/macrophages to an inflammatory phenotype, and that this shift was related to hypertension and hypertensive left...

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Identifiers

PMID: 34493698
DOI: 10.12659/MSM.932404
PMCID: PMC8434772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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