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Genetics of osteopontin in patients with chronic kidney disease: The German Chronic Kidney Disease study

6 Apr 2022

Abstract excerpt

Osteopontin (OPN), encoded by SPP1, is a phosphorylated glycoprotein predominantly synthesized in kidney tissue. Increased OPN mRNA and protein expression correlates with proteinuria, reduced creatinine clearance, and kidney fibrosis in animal models of kidney disease. But its genetic underpinnings are incompletely understood. We therefore conducted a genome-wide association study (GWAS) of OPN in a European...

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PMID: 35385482
DOI: 10.1371/journal.pgen.1010139

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