Article
Next-generation T cell-activating vaccination increases influenza virus mutation prevalence.
Science advances - 8 Apr 2022
Bull Maireid B, Gu Haogao, Ma Fionn N L, Perera Liyanage P, Poon Leo L M, Valkenburg Sophie A
Abstract excerpt
To determine the potential for viral adaptation to T cell responses, we probed the full influenza virus genome by next-generation sequencing directly ex vivo from infected mice, in the context of an experimental T cell-based vaccine, an H5N1-based viral vectored vaccinia vaccine Wyeth/IL-15/5Flu, versus the current standard-of-care, seasonal inactivated influenza vaccine (IIV) and unvaccinated conditions....
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