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Article

IL-15 adjuvanted multivalent vaccinia-based universal influenza vaccine requires CD4 <sup>+</sup> T cells for heterosubtypic protection

31 Mar 2014

Abstract excerpt

Current influenza vaccines are ineffective against novel viruses and the source or the strain of the next outbreak of influenza is unpredictable; therefore, establishing universal immunity by vaccination to limit the impact of influenza remains a high priority. To meet this challenge, a novel vaccine has been developed using the immunogenic live vaccinia virus as a vaccine vector, expressing multiple H5N1 viral...

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PMID: 24706798
DOI: 10.1073/pnas.1403684111

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