Article
Genetic architecture of RNA editing regulation in Alzheimer's disease across diverse ancestral populations.
Human molecular genetics - 25 Aug 2022
Gardner Olivia K, Van Booven Derek, Wang Lily, Gu Tianjie, Hofmann Natalia K, Whitehead Patrice L, Nuytemans Karen, Hamilton-Nelson Kara L, Adams Larry D, Starks Takiyah D, Cuccaro Michael L, Martin Eden R, Vance Jeffery M, Bush William S, Byrd Goldie S, Haines Jonathan L, Beecham Gary W, Pericak-Vance Margaret A, Griswold Anthony J
Abstract excerpt
Most Alzheimer's disease (AD)-associated genetic variants do not change protein coding sequence and thus likely exert their effects through regulatory mechanisms. RNA editing, the post-transcriptional modification of RNA bases, is a regulatory feature that is altered in AD patients that differs across ancestral backgrounds. Editing QTLs (edQTLs) are DNA variants that influence the level of RNA editing at a...
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