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Article

Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes.

Genome biology - 9 Mar 2021

Park Eddie, Jiang Yan, Hao Lili, Hui Jingyi, Xing Yi

Abstract excerpt

BACKGROUND: A-to-I RNA editing diversifies the transcriptome and has multiple downstream functional effects. Genetic variation contributes to RNA editing variability between individuals and has the potential to impact phenotypic variability. RESULTS: We analyze matched genetic and transcriptomic data in 49 tissues across 437 individuals to identify RNA editing events that are associated with genetic variation....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33685485
DOI: 10.1186/s13059-021-02287-1
PMCID: PMC7942016

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