Article
Diverse selective regimes shape genetic diversity at ADAR genes and at their coding targets.
RNA biology - 1 Jan 2015
Forni Diego, Mozzi Alessandra, Pontremoli Chiara, Vertemara Jacopo, Pozzoli Uberto, Biasin Mara, Bresolin Nereo, Clerici Mario, Cagliani Rachele, Sironi Manuela
Abstract excerpt
A-to-I RNA editing operated by ADAR enzymes is extremely common in mammals. Several editing events in coding regions have pivotal physiological roles and affect protein sequence (recoding events) or function. We analyzed the evolutionary history of the 3 ADAR family genes and of their coding targ...
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