Article
RNA editing alterations in a multi-ethnic Alzheimer disease cohort converge on immune and endocytic molecular pathways.
Human molecular genetics - 15 Sept 2019
Gardner Olivia K, Wang Lily, Van Booven Derek, Whitehead Patrice L, Hamilton-Nelson Kara L, Adams Larry D, Starks Takiyah D, Hofmann Natalia K, Vance Jeffery M, Cuccaro Michael L, Martin Eden R, Byrd Goldie S, Haines Jonathan L, Bush William S, Beecham Gary W, Pericak-Vance Margaret A, Griswold Anthony J
Abstract excerpt
Little is known about the post-transcriptional mechanisms that modulate the genetic effects in the molecular pathways underlying Alzheimer disease (AD), and even less is known about how these changes might differ across diverse populations. RNA editing, the process that alters individual bases of RNA, may contribute to AD pathogenesis due to its roles in neuronal development and immune regulation. Here, we...
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