Isocitrate dehydrogenase (IDH) 1 and 2 mutations predict better outcome in patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation: a study of the ALWP of the EBMT.

doi:10.1038/s41409-024-02384-2

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Isocitrate dehydrogenase (IDH) 1 and 2 mutations predict better outcome in patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation: a study of the ALWP of the EBMT.

Bone marrow transplantation - 1 Nov 2024

Mohty Razan, Bazarbachi Abdul Hamid, Labopin Myriam, Esteve Jordi, Kröger Nicolaus, Cornelissen Jan J, Blaise Didier, Socié Gerard, Maury Sébastien, Ganser Arnold, Gedde-Dahl Tobias, von dem Borne Peter, Bourhis Jean Henri, Bulabois Claude Eric, Yakoub-Agha Ibrahim, Pabst Caroline, Nguyen Stéphanie, Chevallier Patrice, Huynh Anne, Bazarbachi Ali, Nagler Arnon, Ciceri Fabio, Mohty Mohamad

Abstract excerpt

Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) mutations have uncertain prognostic implications in AML. We investigate the impact IDH1 and IDH2 mutations in AML patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) in first complete remission (CR1). In total, 1515 adult patients were included, 15.91% (n = 241) carried IDH1 mutation (mIDH1), and 26.27% (n = 398) IDH2 mutation (mIDH2) and...

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PMID: 39143183
DOI: 10.1038/s41409-024-02384-2

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