Article
The impact of rare protein coding genetic variation on adult cognitive function.
Nature genetics - 1 Jun 2023
Chen Chia-Yen, Tian Ruoyu, Ge Tian, Lam Max, Sanchez-Andrade Gabriela, Singh Tarjinder, Urpa Lea, Liu Jimmy Z, Sanderson Mark, Rowley Christine, Ironfield Holly, Fang Terry, Daly Mark, Palotie Aarno, Tsai Ellen A, Huang Hailiang, Hurles Matthew E, Gerety Sebastian S, Lencz Todd, Runz Heiko
Abstract excerpt
Compelling evidence suggests that human cognitive function is strongly influenced by genetics. Here, we conduct a large-scale exome study to examine whether rare protein-coding variants impact cognitive function in the adult population (n = 485,930). We identify eight genes (ADGRB2, KDM5B, GIGYF1, ANKRD12, SLC8A1, RC3H2, CACNA1A and BCAS3) that are associated with adult cognitive function through rare coding...
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