Article
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
Proceedings of the National Academy of Sciences of the United States of America - 23 Sept 2014
Rietveld Cornelius A, Esko Tõnu, Davies Gail, Pers Tune H, Turley Patrick, Benyamin Beben, Chabris Christopher F, Emilsson Valur, Johnson Andrew D, Lee James J, de Leeuw Christiaan, Marioni Riccardo E, Medland Sarah E, Miller Michael B, Rostapshova Olga, van der Lee Sven J, Vinkhuyzen Anna A E, Amin Najaf, Conley Dalton, Derringer Jaime, van Duijn Cornelia M, Fehrmann Rudolf, Franke Lude, Glaeser Edward L, Hansell Narelle K, Hayward Caroline, Iacono William G, Ibrahim-Verbaas Carla, Jaddoe Vincent, Karjalainen Juha, Laibson David, Lichtenstein Paul, Liewald David C, Magnusson Patrik K E, Martin Nicholas G, McGue Matt, McMahon George, Pedersen Nancy L, Pinker Steven, Porteous David J, Posthuma Danielle, Rivadeneira Fernando, Smith Blair H, Starr John M, Tiemeier Henning, Timpson Nicholas J, Trzaskowski Maciej, Uitterlinden André G, Verhulst Frank C, Ward Mary E, Wright Margaret J, Davey Smith George, Deary Ian J, Johannesson Magnus, Plomin Robert, Visscher Peter M, Benjamin Daniel J, Cesarini David, Koellinger Philipp D
Abstract excerpt
We identify common genetic variants associated with cognitive performance using a two-stage approach, which we call the proxy-phenotype method. First, we conduct a genome-wide association study of educational attainment in a large sample (n = 106,736), which produces a set of 69 education-associated SNPs. Second, using independent samples (n = 24,189), we measure the association of these education-associated SNPs...
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