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Replication Stress Is an Actionable Genetic Vulnerability in Desmoplastic Small Round Cell Tumors

16 Oct 2024

Abstract excerpt

Desmoplastic small round cell tumor (DSRCT) is an aggressive sarcoma subtype that is driven by the EWS-WT1 chimeric transcription factor. The prognosis for DSRCT is poor, and major advances in treating DSRCT have not occurred for over two decades. To identify effective therapeutic approaches to target DSRCT, we conducted a high-throughput drug sensitivity screen in a DSRCT cell line assessing chemosensitivity...

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PMID: 39412947
DOI: 10.1158/0008-5472.can-23-3603

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